The United Nations human rights office said on Friday that an Israeli offensive in Gaza's border town of Rafah could not be allowed to happen because it would cause massive loss of Palestinian lives.
"Should Israel launch its threatened military offensive into Rafah, where 1.5 million people have been displaced in deplorable, subhuman conditions, any ground assault on Rafah would incur massive loss of life and would heighten the risk of further atrocity crimes," said Jeremy Laurence, spokesperson for the UN Human Rights Office.
"This must not be allowed to happen."
Defying international calls to halt its military operation, Prime Minister Benjamin Netanyahu said on Thursday that Israel would push on with its offensive against the Hamas movement that runs Gaza, including into Rafah, which he described as "the last Hamas stronghold".
Israel has also said it is reviewing possible curbs on access to Al Aqsa mosque in Jerusalem over Ramadan as Hamas called for Palestinians to march to the mosque at the start of the holy month of Ramadan.
"We also fear that further Israeli restrictions on access by Palestinians to East Jerusalem and the Al Aqsa mosque during Ramadan could further inflame tensions," Laurence said.
Israel pounded Lebanon with more than 120 air strikes on Tuesday in one of the heaviest days of bombing in weeks, Lebanese security sources said, as Israeli Prime Minister Benjamin Netanyahu said his military was deepening its operations in the country.
Syria's transitional leadership has located remnants of former President Bashar al-Assad's clandestine chemical weapons programme, including raw materials and munitions similar to those used to carry out deadly gas attacks during the country's long-running civil war.
US President Donald Trump, who turns 80 next month, said "everything checked out perfectly" after having his physical on Tuesday at Walter Reed National Military Medical ​Center, following a year of public attention on apparently minor health issues.
US Secretary of State Marco Rubio said on Tuesday negotiating a deal with Iran could "take a few days," quashing hopes for an imminent end to the conflict a day after US forces conducted what Washington called defensive strikes in southern Iran.