Nicaragua is breaking off diplomatic relations with Israel, the Central American nation said on Friday, calling the Israeli government "fascist" and "genocidal."
Nicaragua's government, in a statement, said the break in relations was due to Israel's attacks on Palestinian territories.
The nation's congress had, earlier in the day, passed a resolution requesting Nicaragua take action to coincide with the one-year anniversary of the Gaza war.
The conflict, the Nicaraguan government said, now also "extends against Lebanon and gravely threatens Syria, Yemen and Iran."
The Middle East is on high alert for further regional escalation after Iran launched a barrage of missiles at Israel on October 1.
Iran is also an ally of Nicaraguan President Daniel Ortega's administration. Nicaragua has become increasingly isolated in recent years after Ortega cracked down on anti-government protests in 2018, which rights groups say left around 300 dead.
Israel pounded Lebanon with more than 120 air strikes on Tuesday in one of the heaviest days of bombing in weeks, Lebanese security sources said, as Israeli Prime Minister Benjamin Netanyahu said his military was deepening its operations in the country.
Syria's transitional leadership has located remnants of former President Bashar al-Assad's clandestine chemical weapons programme, including raw materials and munitions similar to those used to carry out deadly gas attacks during the country's long-running civil war.
US President Donald Trump, who turns 80 next month, said "everything checked out perfectly" after having his physical on Tuesday at Walter Reed National Military Medical Center, following a year of public attention on apparently minor health issues.
US Secretary of State Marco Rubio said on Tuesday negotiating a deal with Iran could "take a few days," quashing hopes for an imminent end to the conflict a day after US forces conducted what Washington called defensive strikes in southern Iran.