Real Madrid suffered a 3-2 defeat at home against Shakhtar Donetsk in their Champions League Group B opener on Wednesday.
The Ukrainian side raced into a 3-0 lead in the first half with a strike from Brazilian midfielder Tete, an own goal from Madrid defender Raphael Varane and a fine goal from Israeli forward Manor Solomon.
Luka Modric and substitute Vinicius Jr score Madrid's consolation goals in the second half.
Inter Milan were held to a 2-2 draw by Borussia Monchengladbach in the other Group B encounter.
Elsewhere, in Group A, defending champions Bayern Munich crushed Atletico Madrid 4-0 with winger Kingsley Coman scoring a brace, while Salzburg and Lokomotiv played out a 2-2 draw.
In Group C, Manchester City beat Porto 3-1 and Olympiakos overcame Marseille 1-0.
Meanwhile, in Group D, Liverpool edged Ajax 1-0 and Italian side Atalanta thrashed Denmark's Midtjylland 4-0.
Noskova beats Gauff to reach WTA Finals semis, Pegula stays in hunt
Etihad Airways and McLaren Racing take to the skies with racing team livery
Hamilton visits Rafah crossing to witness Gaza aid efforts
Budapest set for star-studded Total Chess World Championship Tour pilot
