Real Madrid suffered a 3-2 defeat at home against Shakhtar Donetsk in their Champions League Group B opener on Wednesday.
The Ukrainian side raced into a 3-0 lead in the first half with a strike from Brazilian midfielder Tete, an own goal from Madrid defender Raphael Varane and a fine goal from Israeli forward Manor Solomon.
Luka Modric and substitute Vinicius Jr score Madrid's consolation goals in the second half.
Inter Milan were held to a 2-2 draw by Borussia Monchengladbach in the other Group B encounter.
Elsewhere, in Group A, defending champions Bayern Munich crushed Atletico Madrid 4-0 with winger Kingsley Coman scoring a brace, while Salzburg and Lokomotiv played out a 2-2 draw.
In Group C, Manchester City beat Porto 3-1 and Olympiakos overcame Marseille 1-0.
Meanwhile, in Group D, Liverpool edged Ajax 1-0 and Italian side Atalanta thrashed Denmark's Midtjylland 4-0.
Substitute Jhon Duran scored two late goals as Aston Villa fought back to salvage a 3-3 home draw with Liverpool on Monday and take a significant step towards a place in the Champions League next season.
Arsenal's Leandro Trossard capitalised on dreadful defending to secure a 1-0 win against Manchester United that saw the Gunners climb back to the top of the Premier League, ensuring the title race will be decided on the final day.
UAE Team Emirates rider Tadej Pogacar has retained his overall lead after Dutchman Olav Kooij won stage nine of the Giro d'Italia on Sunday, pipping Jonathan Milan by half a wheel right at the finish line in a breathless sprint at the end of a 214-km ride from Avezzano to Naples.
Rory McIIroy claimed his fourth Wells Fargo Championship after a superb back nine saw him finish -17 par having trailed by two shots after seven holes.