Novak Djokovic begins his Australian Open title defence against Jeremy Chardy after the draw for the year's first Grand Slam was made on Friday.
World number one Djokovic captured a record-extending eighth title at Melbourne Park last year by beating Dominic Thiem, who is seeded third and faces Mikhail Kukushkin.
Rafael Nadal, seeking a first title at the major since 2009, faces Laslo Djere in his opener.
Reigning women's champion Sofia Kenin will meet wildcard Maddison Inglis.
Top-ranked Ash Barty resumes her quest to become the first homegrown singles winner at the Australian Open since 1978 when the 24-year-old takes on Danka Kovinic.
American Serena Williams, looking to win a record-equalling 24th Grand Slam, meets Laura Siegemund in the opening round while 2019 champion Naomi Osaka faces Anastasia Pavlyuchenkova.
Captains will be the only ones allowed to speak to the referee and discuss a decision during matches at the upcoming European Championship in a bid to facilitate clearer communication.
Substitute Jhon Duran scored two late goals as Aston Villa fought back to salvage a 3-3 home draw with Liverpool on Monday and take a significant step towards a place in the Champions League next season.
Arsenal's Leandro Trossard capitalised on dreadful defending to secure a 1-0 win against Manchester United that saw the Gunners climb back to the top of the Premier League, ensuring the title race will be decided on the final day.
UAE Team Emirates rider Tadej Pogacar has retained his overall lead after Dutchman Olav Kooij won stage nine of the Giro d'Italia on Sunday, pipping Jonathan Milan by half a wheel right at the finish line in a breathless sprint at the end of a 214-km ride from Avezzano to Naples.