England bowled West Indies out for 45 - the second lowest total in international Twenty20 history - to win by 137 runs in St Kitts.
Joe Root's 55 runs and Sam Billings' brilliant knock of 87 off 47 balls helped to win with ease, taking an unassailable 2-0 lead in the series.
This is England's biggest margin of victory by runs in T20s and the fourth biggest of all time.
The final T20 will be played in St Kitts at 20:00 GMT on Sunday.
Rohit and Kohli bid likely farewell to Australia as winners
Rohit Sharma hit a century and Virat Kohli a bright 74 to drive India to a nine-wicket win in the third one-day international on Saturday, sending fans home happy after what are likely to be their final appearances in Australia in their country's colours.
Al Wahda defeats Al Dhafra, heads to quarter-finals of UAE President's Cup
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Bencic battles past Kenin to set up Noskova final in Tokyo
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Lionel Messi tallies twice as Inter Miami take opener vs. Nashville
Lionel Messi scored twice and added an assist to lift Inter Miami to a 3-1 victory over Nashville SC in the opening game of their first-round MLS playoff series on Friday in Fort Lauderdale, Fla.
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