Jason Roy and captain Joe Root both smashed centuries as the tourists easily reached their target of 361 with eight balls to spare in Barbados.
It was their highest ever run-chase in the format.
Chris Gayle's innings of 139 off 129 balls went in vain as the Windies' poor form in ODI cricket continued.
The second encounter of the five-match series will be played on Friday.
UAE achieves another gold medal at Dakar 2026 Youth Olympic Games
UAE's Saeed Omar has won gold in the men’s 400m at the Youth Olympic Games in Senegal's Dakar, adding another medal to the delegations best-ever haul at the sports championship.
Sabalenka, Andreeva make winning starts at WTA Finals
World number two Aryna Sabalenka got her WTA Finals campaign off to a winning start with a hard-fought victory over Karolina Muchova, while Mirra Andreeva eased past Elina Svitolina as Group 2 action got underway on Monday.
Brady ends three-year spell as Birmingham City investor
Tom Brady has ended his three-year involvement as a minority investor in Birmingham City, the English second-tier club said on Monday, thanking the seven-times Super Bowl champion for his support.
Gauff outruns Pegula to win thriller at WTA Finals
Coco Gauff shredded her shoes but stayed one step ahead of Jessica Pegula to defeat her compatriot 6-4 6-7(5) 6-2 on the first day of the WTA Finals at Indian Wells on Sunday, while Czech Linda Noskova got the better of Marta Kostyuk 6-2 6-4.
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