England beat Ireland and France by 12 and 36 points respectively in their first two matches of the campaign.
They are currently ranked third in the world.
Play from the Millennium Stadium in Cardiff gets underway at 8:45 PM UAE time.
Meanwhile Scotland travel to France for their latest Six Nations fixture.
Action from the Stade de France starts at 6:15 PM UAE time.
Romelu Lukaku makes Belgium's World Cup roster
Romelu Lukaku was named to Belgium's 26-man World Cup roster on Friday despite the team's all-time leading scorer being limited to only five appearances for Napoli this season due to injuries.
France reveals World Cup roster; Camavinga, Chevalier left off
France's World Cup roster includes a star-studded assortment of talent, with Real Madrid infielder Eduardo Camavinga arguably the most notable omission.
Punjab crack under pressure to leave IPL playoffs hopes in balance
Punjab Kings set the early pace in the Indian Premier League by going seven matches unbeaten, but a run of five straight defeats has left their playoffs hopes in the balance and assistant coach Brad Haddin concedes they have failed to deal with the pressure.
Mbappe booed on return as Real Madrid beat Oviedo 2-0
Kylian Mbappe was greeted with a chorus of boos and whistles from Real Madrid's own fans as he returned from a hamstring injury during his side's 2-0 LaLiga home win over Real Oviedo on Thursday.
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