According to manager Ole Gunnar Solskjaer, the France midfielder needs an operation on his ankle.
The 26-year-old only made his comeback last month, as his ankle problem kept him out since late September last year.
Scott McTominay is currently also out injured.
Pogba has played only eight times this season after having surgery to correct another ankle injury.
Noskova beats Gauff to reach WTA Finals semis, Pegula stays in hunt
Linda Noskova secured her place in the semi-finals of the WTA Finals with a 6-3 6-3 victory over Coco Gauff on Tuesday, while Jessica Pegula knocked Marta Kostyuk out of the season-ending tournament with a straight-sets win.
Etihad Airways and McLaren Racing take to the skies with racing team livery
Etihad Airways has unveiled a striking livery carrying the branding of partner McLaren Racing, marking the first time a Formula 1 team has been featured on a wide-body aircraft.
Hamilton visits Rafah crossing to witness Gaza aid efforts
Seven-times Formula One world champion Lewis Hamilton arrived in Egypt's El Arish on Tuesday to see first hand efforts to receive humanitarian and relief aid bound for the Gaza Strip.
Budapest set for star-studded Total Chess World Championship Tour pilot
The chess world's biggest stars have descended on Budapest as anticipation builds for the Total Chess World Championship Tour pilot, an ambitious new tournament bringing together 24 of the world's elite players to test an innovative format and explore a new direction for professional chess.
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